Patrícia Figueiredo
Current positions:
Professor, Department of Bioengineering, Instituto Superior Técnico, ULisboa
Principal Investigator, LaSEEB, Institute for Systems and Robotics – Lisboa
Contact:
Email: patricia.figueiredo@tecnico.ulisboa.pt
Phone :+351-218418277 (Internal: 2277)
Office: 6.22 (North Tower, 6th floor)
Researcher profile:
Research interests:
I am interested in imaging human brain function noninvasively, by exploiting the wonderful versatility and never-ending possibilities of magnetic resonance imaging (MRI), and by combining this with the highly complementary technique of electroencephalography (EEG) whenever appropriate. In one line of research, I seek to obtain more quantitative measures of brain function by evaluating the underlying cerebrovascular dynamics through the integration of multiple MRI techniques, including imaging of tissue perfusion and cerebrovascular reactivity. Another line of research involves the multimodal combination of EEG with functional MRI, with the aim of assessing the spatial-temporal dynamics of brain networks. Overall, I expect that these developments will help elucidate the investigation of brain function, in healthy individuals as well as in patients suffering from neurological and psychiatric disorders. Furthermore, I hope to leverage advanced brain imaging techniques to improve noninvasive neuromodulation approaches aimed at repairing brain function, particularly through neurofeedback training. Specifically, I have been focused on applications in the paroxysmal disorders of epilepsy and migraine, in cerebrovascular diseases associated with dementia and stroke, in gliomas, and also in schizophrenia and depression.
Bio sketch:
I graduated in Physics Engineering from Instituto Superior Técnico (IST), Universidade Técnica de Lisboa, in 1996, and obtained the DPhil degree in Neuroimaging from the University of Oxford in 2003. I subsequently held postdoctoral fellowships at Faculdade de Medicina, Universidade de Coimbra, and Faculdade de Ciências, Universidade de Lisboa, before joining IST in 2007 as Assistant Professor with the Physics Department. I was a founding member of the Department of Bioengineering (DBE) at IST in 2011, where I obtained my Tenure in 2011, was conferred Habilitation in Biomedical Engineering in 2017, and was promoted to Associated Professor in 2020 and to Full Professor in 2023. Since 2010, I have been Principal Investigator at the Evolutionary Systems and Biomedical Engineering Lab (LaSEEB) of the Institute for Systems and Robotics – Lisboa (ISR-Lisboa). I have been Honorary Senior Lecturer at the Institute of Neurology, University College London, and Visiting Scientist at the Martinos Center for Biomedical Imaging, the École Polytechnique Fédérale de Lausanne, the Basque Center on Cognition, Brain and Language, and the Politecnico di Milano.
I have been responsible and participated in several national and international research projects in brain imaging, neuroscience and biomedical engineering, and I have been the author of over several papers in international journals of high impact in these fields. My work has been distinguished with the Prize for Women in Science by L’Oréal Portugal, the 2nd best paper award by the Portuguese League against Epilepsy, and the António Xavier Prize for the best Portuguese PhD Thesis (as advisor) in NMR, EPR or MRI. I have supervised and co-supervised several PhD and MSc theses. I have also been the vice-coordinator of the MSc programme in Biomedical Engineering at IST, where I have been responsible for teaching graduate courses in Medical Imaging, Neuroimaging and Neuroengineering. Moreover, I regularly participate in academic management activities within the university, including the Executive Committee of the Department of Bioengineering of IST, where I am currently Vice-President, as well as the Scientific Council of IST and the Scientific Committee of ISR-Lisboa. Internationally, I have been actively involved with the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), as a member of its Education Committee, Chair of the Congress Planning Committee for the 2021 ESMRMB Annual Meeting, and currently Vice-President. I have also been elected Secretary of the Study Group on Current Issues in Brain Function of the International Society for Magnetic Resonance in Medicine (ISMRM).
Research grants (as PI or Co-PI):
HIFI-MRI: Analysis of functional brain connectivity using fMRI at ultra-high field (FCT, 2013-2015)
NeuroPhysIm: Non-invasive quantitative imaging of cerebral physiology: application to normal aging and small vessel disease (FCT, 2013-2015)
DynImag: Non-invasive Dynamic Neuroimaging in Epilepsy (FCT, 2011-2013)
NeuroImage: Neuroimaging investigation of learning mechanisms in the human brain: new methodological approaches (FCT, 2008-2011)
VisMem: Perceptual memory in the human visual system (BIAL, 2006-2010)
VisMemMCI: Perceptual memory in the human visual system: relation with other memory systems in health and mild cognitive impairment (FCT, 2005-2009)
PhD Students:
Marta Loureiro, Longitudinal Evaluation of Glioma Patients using Multiparametric MRI. Co-supervision with Prof. Rita Nunes, Instituto Superior Técnico, Universidade de Lisboa, and Dr. Pedro Vilela, Hospital da Luz (2023-present).
Ana Matoso, Leveraging Deep Learning in Brain Magnetic Resonance Imaging: Population Characterization through Synthetic Image Generation and Application in Glioma Patients. Co-supervision with Prof. Rita Nunes, Instituto Superior Técnico, Universidade de Lisboa, and Dr. Pedro Vilela, Hospital da Luz (2023-present).
Catarina Domingos, Quantitative analysis of time-varying functional brain networks accounting for baseline cerebrovascular physiology. Co-supervision with Dr. César Caballero-Gaudes, Basque Center on Cognition, Brain and Language (2022-present).
Catarina Passarinho, Prediction of high-grade glioma progression by quantitative multiparametric Magnetic Resonance Imaging. Co-supervision with Prof. Rita G. Nunes, Instituto Superior Técnico, Universidade de Lisboa, and Dr. Pedro Vilela, Hospital da Luz (2022-present).
Diogo Cardoso, Co-supervision with Prof. Pulkit Grover, Carnegie Mellon University (2022-present).
Sara Monteiro, Perfusion imaging of glioma by arterial spin labelling MRI: from preclinical validation to clinical application. Co-supervision with Dr. Noam Shemesh, Champalimaud Research (2021-present).
Marta Xavier, Investigating the mechanisms of resting-state brain dynamics: computational modelling of concurrent EEG-fMRI networks. Co-supervision with Prof. Gustavo Deco, Universitat Pompeu Fabra, and Dr. Joana Cabral, Universidade do Minho (2021-present).
Neil Mehta, Attention Networks for Functional Connectivity Mapping in Simultaneously Acquired EEG-fMRI. Co-supervision with Prof. Pulkit Grover, Carnegie Mellon University (2019-present).
Inês Esteves, EEG-based biomarkers of chronic pain as a target for neuromodulation treatments. Co-supervision with Prof. Agostinho Rosa,Instituto Superior Técnico, Universidade de Lisboa, and Prof. Isabel Pavão-Martins, Faculdade de Medicina, Universidade de Lisboa (2019-present).
Ana Fouto, Multimodal neuroimaging biomarkers through the migraine cycle. Co-supervision with Prof. Rita Nunes, Instituto Superior Técnico, Universidade de Lisboa, and Dr. Raquel Gil-Gouveia, Hospital da Luz (2019-present).
Amparo Ruiz-Tagle, Emotion processing throughout the migraine cycle. Co-supervision with Prof. Isabel Pavão-Martins, Faculdade de Medicina, Universidade de Lisboa (2018-present).
Mara Alves, More than the sum of its parts: exploring the neural and cognitive processes of semantic integration. Co-supervision with Prof. Ana Luísa Raposo, Faculdade de Psicologia, Universidade de Lisboa (2016-2023).
Janir Ramos da Cruz, EEG signatures of schizophrenia: visual backward masking and microstates. Co-supervision with Prof. Michael Herzog, École Polytechnique Fédérale de Lausanne (EPFL) (2015-2019).
Joana Pinto, Quantitative evaluation of cerebral haemodynamics using magnetic resonance imaging. Co-supervision with Dr. Pedro Vilela, Hospital da Luz (2014-2019).
Rodolfo Abreu, Study of the spatiotemporal dynamics of epileptic activity using simultaneous EEG-fMRI: towards clinical applications. Co-supervision with Dr. Alberto Leal, Centro Hospitalar Psiquiátrico de Lisboa (2013-2017).
Teresa Murta, Investigation of the neurophysiological correlates of fMRI using simultaneous intracranial and scalp EEG. Co-supervision with Prof. Louis Lemieux and Prof. David Carmichael, University College London (2012-2016).
Marco Leite, Modelling human epileptic brain networks. Co-supervision with Prof. Louis Lemieux and Prof. Karl Friston, University College London (2012-2016).
João Jorge, Simultaneous EEG-fMRI at ultrahigh field for the study of human brain function. Co-supervision with Prof. Rolf Gruetter, École Polytechnique Fédérale de Lausanne (EPFL) (2011-2016).
Inês Sousa, Quantitative methods for functional magnetic resonance imaging. Co-supervision with Dr. João Seabra, Siemens S.A. (2009-2013).
Carlos Gomes, Unravelling consciousness using an inattentional blindness priming paradigm. Co-supervision with Prof. Andrew Mayes, University of Manchester (2008-2012).
Course teaching: