Atrial fibrillation (AF) is the most common sustained arrhythmia, with histopathology associated with left atrial wall fibrosis. The gold standard technique for mapping myocardium fibrosis is MRI with late gadolinium enhancement (LGE). Despite providing quantitative measurements, LGE analysis is subject-dependent and so objective T1 measurements are actively being researched.
A high signal-to-noise ratio is required to achieve sufficient spatial resolution for full atrial T1 mapping, which is hard to obtain at 1.5T. To address this need, we are developing methods for atrial T1 mapping in AF patients at 3.0T in collaboration with Dr. António Ferreira (Hospital da Luz) and Dr. Claudia Prieto Vasquez (Lecturer at King’s College London).